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Role of interferon-beta in Mycobacterium avium subspecies paratuberculosis antibody response in Sardinian MS patients

Frau, Jessica and Cossu, Davide and Coghe, Giancarlo and Lorefice, Lorena and Fenu, Giuseppe and Porcu, Gianluca and Sardu, Claudia and Murru, Maria Rita and Tranquilli, Stefania and Marrosu, Maria Giovanna and Sechi, Leonardo Antonio and Cocco, Eleonora (2015) Role of interferon-beta in Mycobacterium avium subspecies paratuberculosis antibody response in Sardinian MS patients. Journal of the neurological sciences, Vol. 349 (1-2), p. 249-250. ISSN 0022-510X. eISSN 1878-5883. Article.

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DOI: 10.1016/j.jns.2015.01.004

Abstract

Background: Mycobacterium avium subspecies paratuberculosis (MAP) is associated with MS in Sardinia. Because anti-MAP antibodies (Abs) were more frequent in interferon-beta treated patients, we hypothesize that interferon-beta could interact with the immune system.
Methods: Anti-MAP Abs were searched in the blood of 89 patients before commencing interferon-beta and after at least six months.
Results: Anti-MAP Abswere detected before and during treatment in 18.7% and 34.7% of patients, respectively. Twenty-three (20.5%) patients became positive during therapy, and 5 (4.4%) patients became negative (p = 0.001).
Conclusions: The study supports the hypothesis that interferon-beta could interact with the immune system, enhancing the immunological response against MAP.

Item Type:Article
ID Code:10806
Status:Published
Refereed:Yes
Uncontrolled Keywords:Mycobacterium avium subspecies paratuberculosis, Multiple sclerosis, interferon-beta, molecular mimicry, endocellular pathogen, immunomodulation
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Elsevier
ISSN:0022-510X
eISSN:1878-5883
Deposited On:18 Feb 2015 10:07

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