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Polymeric nanoparticles encapsulating white tea extract for nutraceutical application

Sanna, Vanna and Lubinu, Giuseppe and Madau, Pierluigi and Pala, Nicolino and Nurra, Salvatore and Mariani, Alberto and Sechi, Mario (2015) Polymeric nanoparticles encapsulating white tea extract for nutraceutical application. Journal of agricultural and food chemistry, Vol. 63 (7), p. 2026-2032. ISSN 0021-8561. eISSN 1520-5118. Article.

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DOI: 10.1021/jf505850q

Abstract

With the aim to obtain controlled release and to preserve the antioxidant activity of the polyphenols, nanoencapsulation of white tea extract into polymeric nanoparticles (NPs) based on poly(ε-caprolactone) (PCL) and alginate was successfully performed. NPs were prepared by nanoprecipitation method and were characterized in terms of morphology and chemical properties. Total polyphenols and catechins contents before and after encapsulation were determined. Moreover, in vitro release profiles of encapsulated polyphenols from NPs were investigated in simulated gastrointestinal fluids. The antioxidant activity and stability of encapsulated extract were further evaluated. Interestingly, NPs released 20% of the polyphenols in simulated gastric medium, and 80% after 5 h at pH 7.4, showing a good capacity to control the polyphenols delivery. Furthermore, DPPH• assay confirmed that white tea extract retained its antioxidant activity and NPs protected tea polyphenols from degradation, thus opening new perspectives for the exploitation of white tea extract-loaded NPs for nutraceutical applications.

Item Type:Article
ID Code:10793
Status:Published
Refereed:Yes
Uncontrolled Keywords:White tea extract, nanoparticles, controlled release, antioxidant activity
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Area 03 - Scienze chimiche > CHIM/04 Chimica industriale
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > Porto Conte Ricerche, Alghero
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:American Chemical Society
ISSN:0021-8561
eISSN:1520-5118
Deposited On:11 Feb 2015 12:15

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