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Xerostomia induced by radiotherapy: an overview of the physiopathology, clinical evidence, and management of the oral damage

Pinna, Roberto and Campus, Guglielmo Giuseppe and Cumbo, Enzo Maria Giuseppe and Mura, Ida Iolanda and Milia, Egle Patrizia (2015) Xerostomia induced by radiotherapy: an overview of the physiopathology, clinical evidence, and management of the oral damage. Therapeutics and clinical risk management, Vol. 11 , p. 171-188. ISSN 1176-6344. eISSN 1178-2048. Article.

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DOI: 10.2147/TCRM.S70652

Abstract

Background: The irradiation of head and neck cancer (HNC) often causes damage to the salivary glands. The resulting salivary gland hypofunction and xerostomia seriously reduce the patient’s quality of life.
Purpose: To analyze the literature of actual management strategies for radiation-induced hypofunction and xerostomia in HNC patients.
Methods: MEDLINE/PubMed and the Cochrane Library databases were electronically evaluated for articles published from January 1, 1970, to June 30, 2013. Two reviewers independently screened and included papers according to the predefined selection criteria.
Results: Sixty-one articles met the inclusion criteria. The systematic review of the literature suggests that the most suitable methods for managing the clinical and pathophysiological consequences of HNC radiotherapy might be the pharmacological approach, for example, through the use of cholinergic agonists when residual secretory capacity is still present, and the use of salivary substitutes. In addition, a modified diet and the patient’s motivation to enhance oral hygiene can lead to a significant improvement.
Conclusion: Radiation-induced xerostomia could be considered a multifactorial disease. It could depend on the type of cancer treatment and the cumulative radiation dose to the gland tissue. A preventive approach and the correct treatment of the particular radiotherapeutic patient can help to improve the condition of xerostomia.

Item Type:Article
ID Code:10780
Status:Published
Refereed:Yes
Uncontrolled Keywords:Radiation-induced xerostomia, salivary gland hypofunction, management strategies
Subjects:Area 06 - Scienze mediche > MED/42 Igiene generale e applicata
Area 06 - Scienze mediche > MED/28 Malattie odontostomatologiche
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Chirurgiche, Microchirurgiche e Mediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Dove Medical Press
ISSN:1176-6344
eISSN:1178-2048
Copyright Holders:© 2015 Pinna et al.
Deposited On:10 Feb 2015 11:26

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