Colombo, Delia and Abbruzzese, Giovanni and Antonini, Angelo and Barone, Paolo and Bellia, Gilberto and Franconi, Flavia and Simoni, Lucia and Attar, Mahmood and Zagni, Emanuela and Haggiag, Shalom and Stocchi, Fabrizio (2015) The "Gender factor" in wearing-off among patients with Parkinson’s disease: a post hoc analysis of DEEP study. Scientific World Journal, Vol. 2015 , Article 787451. ISSN 2356-6140. eISSN 1537-744X. Article.
Background. The early detection of wearing-off in Parkinson disease (DEEP) observational study demonstrated that women with Parkinson’s disease (PD) carry an increased risk (80.1%) for wearing-off (WO). This post hoc analysis of DEEP study evaluates gender differences onWO and associated phenomena. Methods. Patients on dopaminergic treatment for ≥1 year were included in this multicenter observational cross-sectional study. In a single visit, WO was diagnosed based on neurologist assessment as well as the use of the 19-item wearing-off questionnaire (WOQ-19);WO was defined for scores ≥2. Post hoc analyses were conducted to investigate gender difference for demographic and clinical features with respect toWO. Results. Of 617 patients enrolled, 236 were women and 381 were men. Prevalence of WO was higher among women, according to both neurologists’ judgment (61.9% versus 53.8%, P = 0.045) and theWOQ-19 analysis (72.5% versus 64.0%, P = 0.034). In patients withWO (WOQ-19), women experienced ≥1 motor symptom in 72.5% versus 64.0% in men and ≥1 nonmotor symptom in 44.5% versus 36.7%, in men. Conclusions. Our results suggestWO as more common among women, for both motor and nonmotor symptoms. Prospective studies are warranted to investigate this potential gender-effect.
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