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Screening method for five commonly used amphetamines in urine by NMR spectroscopy

Nieddu, Maria and Carta, Antonio and Burrai, Lucia and Porcu, Maria Cristina and Culeddu, Nicola and Pirisi, Maria Antonietta and Boatto, Gianpiero (2014) Screening method for five commonly used amphetamines in urine by NMR spectroscopy. Applied Magnetic Resonance, Vol. 45 (2), p. 135-144. ISSN 0937-9347. eISSN 1613-7507. Article.

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DOI: 10.1007/s00723-013-0507-1

Abstract

In the recent years the so-called designer drugs have been diffused dramatically worldwide. Amphetamine psychostimulants are one of the major classes of illicit drugs consumed for recreational purposes in the world. The detection of the illegal substances is important both in the management of their misuse and in the forensic field. Urine matrix is a reliable biological matrix for verifying amphetamines intake in the short and medium term because the excretion of these drugs mainly occurs in urine, where substantial amounts of unchanged drug are present. In response to a growing demand for reliable evidence of amphetamine use, a method for identification and quantitation of amphetamine, methamphetamine, 3,4-methylenedioxy-N-methylamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxy-N-ethylamphetamine in urine has been developed by nuclear magnetic resonance spectroscopy, using electronic reference to access in vivo concentration method. The method showed good linearity. The limits of detection and quantitation of amphetamines analyzed ranging from 1.9–7.9 to 5.8–23.8 µg mL−1, respectively. These data demonstrate that the present method is suitable for detection of these drugs in urine samples, allowing to quantitate the target analytes without any purification step of the matrix.

Item Type:Article
ID Code:10763
Status:Published
Refereed:Yes
Uncontrolled Keywords:Amphetamine, NMR spectroscopy, urine, physical chemistry, organic chemistry
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di chimica biomolecolare, Sassari
Publisher:Springer Vienna
ISSN:0937-9347
eISSN:1613-7507
Deposited On:17 Feb 2015 11:11

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