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Effect of antisecretory therapy on atypical symptoms in gastroesophageal reflux disease

Dore, Maria Pina and Pedroni, Antonietta and Pes, Gianni M and Maragkoudakis, Emanouil and Tadeu, Vincenza and Pirina, Pietro and Realdi, Giuseppe and Delitala, Giuseppe and Malaty, Hoda M. (2007) Effect of antisecretory therapy on atypical symptoms in gastroesophageal reflux disease. Digestive diseases and sciences, Vol. 52 (2), p. 463-468. ISSN 0163-2116. eISSN 1573-2568. Article.

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DOI: 10.1007/s10620-006-9573-7

Abstract

The effect of proton pump inhibitor (PPI) therapy on extraesophageal or atypical manifestations of gastroesophageal reflux disease (GERD) remains unclear. This study aimed to evaluate the prevalence of atypical manifestations in patients with acid reflux disease and the effect of PPI treatment. Patients with symptoms and signs suggestive of reflux were enrolled. Erosive esophagitis was stratified using the Los Angeles classification. Demographic data and symptoms were assessed using a questionnaire and included typical symptoms (heartburn, regurgitation, dysphagia, odynophagia), and atypical symptoms (e.g., chest pain, sialorrhea, hoarseness, globus sensation, chronic coughing, episodic bronchospasm, hiccup, eructations, laryngitis, and pharyngitis). Symptoms were reassessed after a 3-month course of b.i.d. PPI therapy. A total of 266 patients with a first diagnosis of GERD (erosive, 166; nonerosive, 100) were entered in the study. Presentation with atypical symptoms was approximately equal in those with erosive GERD and with nonerosive GERD, 72% vs 79% (P = 0.18). None of the study variables showed a significant association with the body mass index. PPI therapy resulted in complete symptom resolution in 69% (162/237) of the participants, 12% (28) had improved symptoms, and 20% (47) had minimal or no improvement. We conclude that atypical symptoms are frequent in patients with GERD. A trial of PPI therapy should be considered prior to referring these patients to specialists.

Item Type:Article
ID Code:10749
Status:Published
Refereed:Yes
Uncontrolled Keywords:Proton pump inhibitor therapy, chest pain, sialorrhea, hoarseness, globus sensation, chronic coughing, episodic bronchospasm, hiccup, eructations, laryngitis, pharyngitis
Subjects:Area 06 - Scienze mediche > MED/10 Malattie dell'apparato respiratorio
Area 06 - Scienze mediche > MED/12 Gastroenterologia
Area 06 - Scienze mediche > MED/09 Medicina interna
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Springer
ISSN:0163-2116
eISSN:1573-2568
Deposited On:04 Feb 2015 10:32

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