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Reduced intravenous glutathione in the treatment of early parkinson's disease

Sechi, Gianpietro and Deledda, Maria G. and Bua, Guido and Satta, Wanda Maria and Deiana, Giovanni Andrea and Pes, Giovanni Mario and Rosati, Giulio (1996) Reduced intravenous glutathione in the treatment of early parkinson's disease. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 20 (7), p. 1159-1170. ISSN 0278-5846. Article.

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DOI: 10.1016/S0278-5846(96)00103-0

Abstract

1. Several studies have demonstrated a deficiency in reduced glutathione (GSH) in the nigra of patients with Parkinson's Disease (PD). In particular, the magnitude of reduction in GSH seems to parallel the severity of the disease. This finding may indicate a means by which the nigra cells could be therapeutically supported.
2. The authors studied the effects of GSH in nine patients with early, untreated PD. GSH was administered intravenous, 600 mg twice daily, for 30 days, in an open label fashion. Then, the drug was discontinued and a follow-up examination carried-out at 1-month interval for 2–4 months. Thereafter, the patients were treated with carbidopa-levodopa.
3. The clinical disability was assessed by using two different rating scale and the Webster Step-Second Test at baseline and at 1-month interval for 4–6 months. All patients improved significantly after GSH therapy, with a 42% decline in disability. Once GSH was stopped the therapeutic effect lasted for 2–4 months.
4. Our data indicate that in untreated PD patients GSH has symptomatic efficacy and possibly retards the progression of the disease.

Item Type:Article
ID Code:10743
Status:Published
Refereed:Yes
Uncontrolled Keywords:Parkinson's disease, reduced glutathione
Subjects:Area 06 - Scienze mediche > MED/05 Patologia clinica
Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:Elsevier
ISSN:0278-5846
Deposited On:03 Feb 2015 11:17

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