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Gold(I) compounds with lansoprazole-type ligands: synthesis, characterization and anticancer properties in vitro

Serratrice, Maria and Bertrand, Benoit and Janssen, Ellen F. J. and Hemelt, Eline and Zucca, Antonio and Cocco, Fabio and Cinellu, Maria Agostina and Casini, Angela (2014) Gold(I) compounds with lansoprazole-type ligands: synthesis, characterization and anticancer properties in vitro. MedChemComm, Vol. 5 (9), p. 1418-1422. ISSN 2040-2503. eISSN 2040-2511. Article.

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DOI: 10.1039/C4MD00241E

Abstract

A number of gold(I) complexes containing the proton pump inhibitor (PPI) lansoprazole and its reduced precursor 2-((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methylthio)-1H-benzo[d]imidazole have been synthesized and their biological effects have been evaluated in human cancer and non-tumorigenic cells in vitro. The lansoprazole-based compounds appear to act through a V-H+-ATPase-mediated mechanism.

Item Type:Article
ID Code:10739
Status:Published
Refereed:Yes
Uncontrolled Keywords:Gold(I) complexes, Proton Pump Inhibitor (PPI) lansoprazole, biological effects, human cancer
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Royal Society of Chemistry
ISSN:2040-2503
eISSN:2040-2511
Deposited On:02 Feb 2015 17:35

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