Serratrice, Maria and Bertrand, Benoit and Janssen, Ellen F. J. and Hemelt, Eline and Zucca, Antonio and Cocco, Fabio and Cinellu, Maria Agostina and Casini, Angela (2014) Gold(I) compounds with lansoprazole-type ligands: synthesis, characterization and anticancer properties in vitro. MedChemComm, Vol. 5 (9), p. 1418-1422. ISSN 2040-2503. eISSN 2040-2511. Article.
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A number of gold(I) complexes containing the proton pump inhibitor (PPI) lansoprazole and its reduced precursor 2-((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methylthio)-1H-benzo[d]imidazole have been synthesized and their biological effects have been evaluated in human cancer and non-tumorigenic cells in vitro. The lansoprazole-based compounds appear to act through a V-H+-ATPase-mediated mechanism.
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