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Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound

Messori, Luigi and Scaletti, Federica and Massai, Lara and Cinellu, Maria Agostina and Russo Krauss, Irene and Di Martino, Giovanna and Vergara, Alessandro and Paduano, Luigi and Merlino, Antonello (2014) Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound. Metallomics, Vol. 6 (2), p. 233-236. ISSN 1756-5901. eISSN 1756-591X. Article.

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DOI: 10.1039/C3MT00265A

Abstract

The reaction of Auoxo6, a dinuclear gold(III) complex, with the model protein bovine pancreatic ribonuclease is explored here by X-ray diffraction and ESI mass spectrometry. Data provide clues on the processes of adduct formation and of enzyme inhibition and, inductively, on the likely mode of action of this metallodrug.

Item Type:Article
ID Code:10738
Status:Published
Refereed:Yes
Uncontrolled Keywords:Auoxo6, ribonuclease A, X-ray diffraction, ESI mass spectrometry
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:RCS Publishing
ISSN:1756-5901
eISSN:1756-591X
Deposited On:02 Feb 2015 17:16

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