Messori, Luigi and Scaletti, Federica and Massai, Lara and Cinellu, Maria Agostina and Russo Krauss, Irene and Di Martino, Giovanna and Vergara, Alessandro and Paduano, Luigi and Merlino, Antonello (2014) Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound. Metallomics, Vol. 6 (2), p. 233-236. ISSN 1756-5901. eISSN 1756-591X. Article.
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The reaction of Auoxo6, a dinuclear gold(III) complex, with the model protein bovine pancreatic ribonuclease is explored here by X-ray diffraction and ESI mass spectrometry. Data provide clues on the processes of adduct formation and of enzyme inhibition and, inductively, on the likely mode of action of this metallodrug.
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