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Interactions of gold-based drugs with proteins: the structure and stability of the adduct formed in the reaction between lysozyme and the cytotoxic gold(III) compound Auoxo3

Russo Krauss, Irene and Messori, Luigi and Cinellu, Maria Agostina and Marasco, Daniela and Sirignano, Rosalba and Merlino, Antonello (2014) Interactions of gold-based drugs with proteins: the structure and stability of the adduct formed in the reaction between lysozyme and the cytotoxic gold(III) compound Auoxo3. Dalton Transactions, Vol. 43 (46), p. 17483-17488. ISSN 1477-9226. eISSN 1477-9234. Article.

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DOI: 10.1039/C4DT02332C

Abstract

The structure and stability of the adduct formed in the reaction between Auoxo3, a dinuclear gold(III) compound, and the model protein hen egg white lysozyme (HEWL) are investigated by X-ray crystallography, UV-Vis absorption spectroscopy and circular dichroism (CD). It is found that Auoxo3 breaks down completely, undergoes reduction and produces reactive gold(I) species able to bind the protein and form stable derivatives. The behaviour of Auoxo3 is compared with that of two analogous gold(III) complexes previously studied: a few significant differences are highlighted. The general implications of these new results for the mode of action of cytotoxic gold complexes are discussed.

Item Type:Article
ID Code:10731
Status:Published
Refereed:Yes
Uncontrolled Keywords:Auoxo3, hen egg white lysozyme (HEWL), X-ray crystallography, UV-Vis absorption spectroscopy, circular dichroism (CD)
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Royal Society of Chemistry
ISSN:1477-9226
eISSN:1477-9234
Deposited On:02 Feb 2015 11:16

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