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Interactions of selected gold(III) complexes with DNA G quadruplexes

Gratteri, Paolo and Massai, Lara and Michelucci, Elena and Rigo, R. and Messori, Luigi and Cinellu, Maria Agostina and Musetti, Caterina and Sissi, Claudia and Bazzicalupi, Carla (2015) Interactions of selected gold(III) complexes with DNA G quadruplexes. Dalton Transactions, Vol. 44 (8), p. 3633-3639. ISSN 1477-9226. eISSN 1477-9234. Article.

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DOI: 10.1039/C4DT02698E

Abstract

The interactions of three representative gold(III) complexes with human telomeric DNA sequences were analysed using a variety of biophysical methods, including DNA melting, circular dichroism, SPR and ESI MS; remarkable interactions were highlighted for all tested complexes, although they were associated to significantly different binding profiles. The most interesting compound was Auoxo6, a dinuclear gold(III) complex, which beyond manifesting a conspicuous binding affinity for the G-quadruplex conformation, turned out to be very effective in inducing a non-canonical secondary structure. These findings may clear the way for novel biological and pharmacological applications of this class of metal compounds.

Item Type:Article
ID Code:10730
Status:Published
Refereed:Yes
Uncontrolled Keywords:DNA melting, circular dichroism, SPR and ESI MS, Auoxo6
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Royal Society of Chemistry
ISSN:1477-9226
eISSN:1477-9234
Deposited On:02 Feb 2015 10:23

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