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The Mode of action of anticancer gold-based drugs: a structural perspective

Messori, Luigi and Scaletti, Federica and Massai, Lara and Cinellu, Maria Agostina and Gabbiani, Chiara and Vergara, Alessandro and Merlino, Antonello (2013) The Mode of action of anticancer gold-based drugs: a structural perspective. Chemical communications, Vol. 49 (86), p. 10100-10102. eISSN 0009-241X. Article.

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DOI: 10.1039/C3CC46400H


The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug–protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes.

Item Type:Article
ID Code:10729
Uncontrolled Keywords:Anticancer gold-based drugs, egg white lysozyme, X-ray crystallography
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Chemical Society
Deposited On:02 Feb 2015 09:31

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