Messori, Luigi and Scaletti, Federica and Massai, Lara and Cinellu, Maria Agostina and Gabbiani, Chiara and Vergara, Alessandro and Merlino, Antonello (2013) The Mode of action of anticancer gold-based drugs: a structural perspective. Chemical communications, Vol. 49 (86), p. 10100-10102. eISSN 0009-241X. Article.
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The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug–protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes.
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