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Triply phenoxo bridged Eu(III) and Sm(III) complexes with 2,6-diformyl-4-methylphenol-di(benzoylhydrazone): structure, spectra and biological study in human cell lines

Das, Kuheli and Nandi, Soumendra and Mondal, Sudipa and Askun, Tulin and Cantürk, Zerrin and Celikboyun, Pinar and Massera, Chiara and Garribba, Eugenio and Datta, Amithaba and Sinha, Chittaranjan and Akitsug, Takashiro (2015) Triply phenoxo bridged Eu(III) and Sm(III) complexes with 2,6-diformyl-4-methylphenol-di(benzoylhydrazone): structure, spectra and biological study in human cell lines. New Journal of Chemistry, Vol. 39 (2), p. 1101-1114. ISSN 1144-0546. eISSN 1369-9261. Article.

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DOI: 10.1039/c4nj01464b

Abstract

Two dinuclear lanthanide(III) complexes, [M2(HL)3] (M = Sm(III) (1), Eu(III) (2); H3L, 2,6-diformyl-4-methylphenol-di(benzoylhydrazone)) were generated with good yield and characterised systematically. The single crystal X-ray structure determination of [Eu2(HL)3] (2) confirmed the tricapped trigonal prismatic geometry of the N3O6 coordination environment around europium. Indeed, Eu(1) and Eu(2) are bridged by phenolato-O belonging to the p-cresol ring, by deprotonated ‘enol’ groups from the benzoyl hydrazide part and by the imine-N centres. A temperature dependent magnetic study suggested that anti-ferromagnetic coupling occurs between the two Eu(III) ions and the magnetic moment was found to vary from 0.48 B.M. at 5 K to 3.03 B.M. at 300 K. Electron paramagnetic resonance spectroscopy confirmed that anti-ferromagnetic coupling occurs between the atoms of Eu(III) and Sm(III). Both the complexes show emission in the visible range. The ligand, H3L and the complexes exhibit anti-mycobacterial activity against M. tuberculosis H37Rv (ATCC 27294) and M. tuberculosis H37Ra (ATCC 25177) strains. The molecular docking of H3L with the enoyl acyl carrier protein reductase of M. tuberculosis H37Rv (PDB ID: 4U0K) was examined and the best docked pose of H3L was shown to have one hydrogen bond with Thr196 (2.03 Å).

Item Type:Article
ID Code:10727
Status:Published
Refereed:Yes
Uncontrolled Keywords: [M2(HL)3] (M = Sm(III) (1), Eu(III) (2); H3L, 2,6-diformyl-4-methylphenol-di(benzoylhydrazone)), M. tuberculosis H37Rv, M. tuberculosis H37Ra
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Royal Society of Chemistry
ISSN:1144-0546
eISSN:1369-9261
Deposited On:30 Jan 2015 12:58

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