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An in vitro and in vivo comparison of the effect of Stevia rebaudiana extracts on different caries-related variables: a randomized controlled trial pilot study

Brambilla, Elena and Cagetti, Maria Grazia and Ionescu, Ana Maria and Campus, Guglielmo Giuseppe and Lingström, Peter (2014) An in vitro and in vivo comparison of the effect of Stevia rebaudiana extracts on different caries-related variables: a randomized controlled trial pilot study. Caries Research, Vol. 48 (1), p. 19-23. ISSN 0008-6568. eISSN 1421-976X. Article.

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DOI: 10.1159/000351650

Abstract

The effect of Stevia extracts on in vitro Streptococcus mutans biofilm formation and in vivo plaque pH was evaluated in this paper. Three 10% solutions containing stevioside, rebaudioside A or sucrose were prepared. MTT assay was used to evaluate microbiological counts in vitro. Twenty volunteers rinsed for 1 min with each solutions, and plaque pH was measured at 7 time points after each rinse. Higher in vitro S. mutans biofilm formation was observed in sucrose solution (p < 0.01). After 5, 10, 15 and 30 min, the sucrose in vivo rinse produced a statistically significantly lower pH value compared to the Stevia extracts (F = 99.45, p < 0.01). Stevia extracts can be considered nonacidogenic.

Item Type:Article
ID Code:10713
Status:Published
Refereed:Yes
Uncontrolled Keywords:Stevia rebaudiana, Streptococcus mutans, caries
Subjects:Area 06 - Scienze mediche > MED/28 Malattie odontostomatologiche
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Chirurgiche, Microchirurgiche e Mediche
Publisher:Karger
ISSN:0008-6568
eISSN:1421-976X
Deposited On:28 Jan 2015 13:59

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