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Nicotine-induced increase of dopaminergic mesoaccumbal neuron activity is prevented by acute restraint stress: in vivo electrophysiology in rats

Panin, Francesca and Lintas, Alessandra and Diana, Marco (2014) Nicotine-induced increase of dopaminergic mesoaccumbal neuron activity is prevented by acute restraint stress: in vivo electrophysiology in rats. European Neuropsychopharmacology, Vol. 24 (7), p. 1175-1180. ISSN 0924-977X. eISSN 1873-7862. Article.

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DOI: 10.1016/j.euroneuro.2014.01.003

Abstract

Stress is well known to affect responsiveness to drugs of abuse and influencing approaching and drug-taking behaviour in both animals and humans. Consistently, in nicotine addicted subjects both negative events and perceived stress levels are reported to increase drug use and facilitate relapse to smoke even after long periods of abstinence. It has been suggested that stressful stimuli may influence the rewarding properties of abused drugs by acting on the dopaminergic mesolimbic system. In line with this hypothesis, a recent microdialysis study in rats has shown that acute restraint stress exposure prevents the nicotine-induced mesolimbic dopaminergic activation in the nucleus accumbens (NAC) shell via a corticosterone-mediated mechanism. In the present study we sought to evaluate the impact of acute restraint stress on nicotine-induced activation of the mesoaccumbal dopaminergic system by extracellular single unit recordings of antidromically-identified NAC shell projecting dopaminergic neurons within the ventral tegmental area (VTA). Nicotine intravenous administration dose-dependently (0.05–0.4 mg/kg) stimulated the spontaneous firing and bursting of mesoaccumbal dopaminergic neurons in unstressed rats, as previously reported. By contrast, nicotine failed to increase mesoaccumbal dopaminergic neuron activity in rats previously exposed to 1-h immobilisation stress. Our observations show that acute restraint stress inhibits the response of the mesoaccumbal dopaminergic system to the stimulating properties of nicotine. These findings corroborate the notion that stress reduces the sensitivity to nicotine and suggest that the decreased dopaminergic release in the NAC shell is due to a reduced firing and bursting activity in the VTA.

Item Type:Article
ID Code:10684
Status:Published
Refereed:Yes
Uncontrolled Keywords:Nicotine, restraintstress, electrophysiology, mesoaccumbal, dopaminergic system
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Elsevier
ISSN:0924-977X
eISSN:1873-7862
Deposited On:23 Jan 2015 11:59

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