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The Role of Clofarabine in the treatment of adults with acute myeloidleukemia

Fozza, Claudio (2015) The Role of Clofarabine in the treatment of adults with acute myeloidleukemia. Critical reviews in oncology/hematology, Vol. 93 (3), p. 237-245. ISSN 1040-8428. eISSN 1879-0461. Article.

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DOI: 10.1016/j.critrevonc.2014.10.009


The therapeutic scenario available for adult patients with acute myeloid leukemia (AML) has shown only partial progresses over the last few years. This is especially true for refractory and relapsed AML whose outcome is still extremely disappointing. In this context Clofarabine has offered new promising perspectives within first and second line protocols. This review will firstly describe the initial development in monotherapy, considering then the different potential combination strategies which include both polichemotherapeutic regimens and less conventional approaches with new generation drugs. The potential use of Clofarabine as induction treatment for patients candidate to stem cell transplantation and within conditioning regimens will be finally evaluated.

Item Type:Article
ID Code:10678
Uncontrolled Keywords:Clofarabine, adults, Acute myeloid leukemia (AML)
Subjects:Area 06 - Scienze mediche > MED/15 Malattie del sangue
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Deposited On:22 Jan 2015 15:07

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