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Type I IFN family members: similarity, differences and interaction

Capobianchi, Maria Rosaria and Uleri, Elena and Caglioti, Claudia and Dolei, Antonina (2014) Type I IFN family members: similarity, differences and interaction. Cytokine and growth factor reviews , in press. ISSN 1359-6101. eISSN 1879-0305. Article.

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DOI: 10.1016/j.cytogfr.2014.10.011

Abstract

Interferons (IFN) are key cytokines with multifaceted antiviral and cell-modulatory properties. Three distinct types of IFN are recognized (I–III) based on structural features, receptor usage, cellular source and biological activities. The action of IFNs is mediated by a complex, partially overlapping, transcriptional program initiated by the interaction with specific receptors. Genetic diversity, with polymorphisms and mutations, can modulate the extent of IFN responses and the susceptibility to infections. Almost all viruses developed mechanisms to subvert the IFN response, involving both IFN induction and effector mechanisms. Interactions between IFN types may occur, for both antiviral and cell-modulatory effects, in a complex interplay, involving both synergistic and antagonistic effects. Interferon-associated diseases, not related to virus infections may occur, some of them frequently observed in IFN-treated patients. On the whole, IFNs are pleiotropic biologic response modifiers, that, upon activation of thousands genes, induce a broad spectrum of activities, regulating cell cycle, differentiation, plasma membrane molecules, release of mediators, etc., that can be relevant for cell proliferation, innate and adaptive immunity, hematopoiesis, angiogenesis and other body functions.

Item Type:Article
ID Code:10667
Status:Published
Refereed:Yes
Uncontrolled Keywords:Interferon types I–III, interferon genes and receptors, interferon–interferon interactions, anti-interferon strategies
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Elsevier
ISSN:1359-6101
eISSN:1879-0305
Deposited On:21 Jan 2015 15:50

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