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Homochiral metal–organic frameworks and their application in chromatography enantioseparations

Peluso, Paola and Mamane, Victor and Cossu, Sergio Antonio (2014) Homochiral metal–organic frameworks and their application in chromatography enantioseparations. Journal of Chromatography A, Vol. 1363 , p. 11-26. ISSN 0021-9673. eISSN 1873-3778. Article.

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DOI: 10.1016/j.chroma.2014.06.064

Abstract

The last frontier in the chiral stationary phases (CSPs) field for chromatography enantioseparations is represented by homochiral metal-organic frameworks (MOFs), a class of organic-inorganic hybrid materials built from metal-connecting nodes and organic-bridging ligands. The modular nature of these materials allows to design focused structures by combining properly metal, organic ligands and rigid polytopic spacers. Intriguingly, chiral ligands introduce molecular chirality in the MOF-network as well as homochirality in the secondary structure of materials (such as homohelicity) producing homochiral nets in a manner mimicking biopolymers (proteins, polysaccharides) which are characterized by a definite helical sense associated with the chirality of their building blocks (amino acids or sugars). Nowadays, robust and flexible materials characterized by high porosity and surface area became available by using preparative procedures typical of the so-called reticular synthesis. This review focuses on recent developments in the synthesis and applications of homochiral MOFs as supports for chromatography enantioseparations. Indeed, despite this field is in its infancy, interesting results have been produced and a critical overview of the 12 reported applications for gas chromatography (GC) and high-performance liquid chromatography (HPLC) can orient the reader approaching the field. Mechanistic aspects are shortly discussed and a view regarding future trends in this field is provided.

Item Type:Article
ID Code:10665
Status:Published
Refereed:Yes
Uncontrolled Keywords:Chiral stationary phases, GC, enantioseparation, HPLC, metal-organic framework
Subjects:Area 03 - Scienze chimiche > CHIM/06 Chimica organica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di chimica biomolecolare, Sassari
Publisher:Elsevier
ISSN:0021-9673
eISSN:1873-3778
Deposited On:21 Jan 2015 14:04

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