Tonelli, Michele and Novelli, Federica and Tasso, Bruno and Sparatore, Anna and Boido, Vito and Sparatore, Fabio and Cannas, Sara and Molicotti, Paola and Zanetti, Stefania Anna Lucia and Parapini, Silvia and Loddo, Roberta (2014) Antitubercular activity of quinolizidinyl/pyrrolizidinylalkyliminophenazines. Bioorganic & Medicinal Chemistry, Vol. 22 (24), p. 6837-6845. ISSN 0968-0896. eISSN 1464-3391. Article.
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Novel riminophenazine derivatives, characterized by the presence of the basic and cumbersome
quinolizidinylalkyl and pyrrolizidinylethyl moieties, have been synthesized and tested (Rema test)
against Mycobacterium tuberculosis H37Rv and H37Ra, and six clinical isolates of Mycobacterium avium and Mycobacterium tuberculosis. Most compounds exhibited potent activity against the tested strains, resulting more active than clofazimine, isoniazid and ethambutol.
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