titoli, abstracts, parole chiave >>>
Metals in plasma of nonagenarians and centenarians living in a key area of longevity

Forte, Giovanni and Deiana, Maria and Pasella, Sara and Baralla, Angela and Occhineri, Patrizia and Mura, Ida Iolanda and Madeddu, Roberto Beniamino and Muresu, Elena and Sotgia, Salvatore and Zinellu, Angelo and Carru, Ciriaco and Bocca, Beatrice and Deiana, Luca (2015) Metals in plasma of nonagenarians and centenarians living in a key area of longevity. Experimental gerontology, Vol. 60 , p. 197-206. ISSN 0531-5565. eISSN 1873-6815. Article.

Full text not available from this repository.

DOI: 10.1016/j.exger.2014.10.016


The concentration of calcium (Ca), cobalt (Co), copper (Cu), iron (Fe), magnesium (Mg), manganese (Mn) and selenium (Se) in plasma of 76 nonagenarians (mean age, 89.0 ± 6.3 years), 64 centenarians (mean age, 101 ± 1 years) and 24 middle-aged subjects as controls (mean age 61.2 ± 1.1 years), was determined by sector field inductively coupled plasma mass spectrometry. All the subjects lived in Sardinia, an Italian island, that has the higher prevalence of centenarians than in other European countries. A comparison among the three classes of age showed a significant depletion of Ca, Co, Fe, Mn and Se (all p < 0.001) in nonagenarians and centenarians with respect to controls. In particular, the geometric mean (GM) values of Ca, Co, Fe, Mn and Se were: 94.1 μg/ml, 0.46 ng/ml, 1314 ng/ml, 2.47 ng/ml and 111 ng/ml in controls; 87.6 μg/ml, 0.22 ng/ml, 815 ng/ml, 1.07 ng/ml and 88.9 ng/ml in nonagenarians; 87.0 μg/ml, 0.29 ng/ml, 713 ng/ml, 1.27 ng/ml and 81.9 ng/ml in centenarians. The highest inverse relationship with age was observed for Fe (p < 0.001; ρ = − 0.352) and Se (p < 0.001; ρ = − 0.417). This trend was also observed when data were sorted by gender. On the other hand, Cu and Mg levels in plasma remained substantially unchanged during aging. As regards Cu, it was significantly higher in females than in males in controls (GM, 1294 ng/ml vs. 1077 ng/ml; p = 0.012), in nonagenarians (GM, 1216 ng/ml vs. 1081 ng/ml; p = 0.011) as well as in centenarians (GM, 1226 ng/ml vs. 1152 ng/ml; p = 0.045) and in hypertensive subjects with respect to healthy people (GM, 1215 ng/ml vs. 1129 ng/ml; p = 0.021). These data can be used to enhance knowledge and support the research on: i) metals involved in aging in areas with high rates of human longevity; ii) variables (gender, lifestyle habits and health status) as critical determinants in aging; and iii) mineral intake and supplementation at older age affecting the healthy aging.

Item Type:Article
ID Code:10641
Uncontrolled Keywords:Aging, human biomonitoring, metals, plasma
Subjects:Area 05 - Scienze biologiche > BIO/17 Istologia
Area 06 - Scienze mediche > MED/42 Igiene generale e applicata
Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
002 Altri enti e centri di ricerca del Nord Sardegna > Associazione Isola dei Centenari, Sassari
Deposited On:19 Jan 2015 13:18

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page