Rassu, Giovanna and Nieddu, Maria and Bosi, Paolo and Trevisi, Paolo and Colombo, M.M. and Priori, D. and Manconi, Paola Maria and Giunchedi, Paolo and Gavini, Elisabetta and Boatto, Gianpiero (2014) Encapsulation and modified-release of thymol from oral microparticles as adjuvant or substitute to current medications. Phytomedicine, Vol. 21 (12), p. 1627-1632. ISSN 0944-7113. eISSN 1618-095X. Article.
Full text not available from this repository.
The aim of this study was to encapsulate, thymol, in natural polymers in order to obtain (i) taste mask-ing effect and, then, enhancing its palatability and (ii) two formulations for systemic and local deliveryof herbal drug as adjuvants or substitutes to current medications to prevent and treat several humanand animal diseases. Microspheres based on methylcellulose or hydroxypropyl methylcellulose phtha-late (HPMCP) were prepared by spray drying technique. Microparticles were in vitro characterized interms of yield of production, drug content and encapsulation efficiency, particle size, morphology anddrug release. Both formulations were in vivo orally administered and pharmacokinetic analysis wascarried out. The polymers used affect the release and, then, the pharmacokinetic profile of thymol. Encapsulation into methylcellulose microspheres leads to short half/life but bioavailability remarkablyincreases compared to the free thymol. In contrast, enteric formulation based on HPMCP shows verylimited systemic absorption. These formulations could be proposed as alternative or adjuvants for con-trolling pathogen infections in human or animal. In particular, methylcellulose microspheres can be usedfor thymol systemic administration at low doses and HPMCP particles for local treatment of intestinalinfections.
I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore
Repository Staff Only: item control page