Tomei, Sara and Bedognetti, Davide and De Giorgi, Valeria and Sommariva, Michele and Civini, Sara and Reinboth, Jennifer and Al Hashmi, Muna and Ascierto, Maria Libera and Liu, Qiuzhen and Ayotte, Ben D. and Worschech, Andrea and Uccellini, Lorenzo and Ascierto, Paolo Antonio and Stroncek, David F. and Palmieri, Giuseppe and Chouchane, Lotfi and Wang, Ena and Marincola, Francesco M. (2015) The Immune-related role of BRAF in melanoma. Molecular oncology, Vol. 9 (1), p. 93-104. ISSN 1574-7891. eISSN 1878-0261. Article.
Background: The existence of a dichotomy between immunologically active and quiescent, tumor phenotypes has been recently recognized in several types of cancer. The activation of a Th1 type of immune signature has been shown to confer better prognosis and likelihood to respond to immunotherapy. However, whether such dichotomy depends on the genetic make-up of individual cancers is not known yet. BRAF and NRAS mutations are commonly acquired during melanoma progression. Here we explored the role of BRAF
and NRAS mutations in influencing the immune phenotype based on a classification previously identified by our group.
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