Cossu, Davide and Mameli, Giuseppe and Masala, Speranza and Cocco, Eleonora and Frau, Jessica and Marrosu, Maria Giovanna and Sechi, Leonardo Antonio (2014) Evaluation of the humoral response against mycobacterial peptides, homologous to MOG35–55, in multiple sclerosis patients. Journal of the Neurological Sciences, Vol. 347 (1-2), p. 78-81. ISSN 0022-510X. eISSN 1878-5883. Article.
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Bacillus Calmette-Guérin (BCG) and Mycobacterium avium subspecies paratuberculosis (MAP) have been associated with multiple sclerosis (MS). Clinical data indicates that BCG vaccination exerts anti-inflammatory effects in MS; conversely,MAP is thought to be one of the possible infectious factors responsible of MS through a molecular mimicry mechanism.
A peptide-based indirect ELISA was used to detect antibodies against the encephalitogenic myelin oligodendrocyte glycoprotein (MOG)35–55 epitope, and two mycobacterial peptides sharing sequence homology with the latter: MAP_2619c352–361/BCG_1224355–364 and BCG_3329c64–74. Among 40 MS patients and 39 healthy volunteers included in the study, only MOG35–55 was capable of inducing a significantly higher humoral response in
MS subjects compared to controls. Indeed, 11 out of 40 MS subjects (27.5%) and only 2 out of 39 controls (5%)
were antibody-positive for MOG35–55 (p = 0.01, AUC= 0.65).
These findings strengthen the importance ofMOG35–55 inMS pathogenesis. The MAP and BCGMOG-homologues epitopes investigated were not recognized in MS patients. Overall, the results allow us concluding that sharing homology of linear epitopes is necessary but not sufficient to induce antibody-mediated cross-reactivity.
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