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Identification and quantitation of 4-bromo-2,5-dimethoxyamphetamine in seized blotters

Burrai, Lucia and Nieddu, Maria and Palomba, Michele Francesco Luigi and Pirisi, Maria Antonietta (2015) Identification and quantitation of 4-bromo-2,5-dimethoxyamphetamine in seized blotters. Legal Medicine, Vol. 17 (1), p. 56-59. ISSN 1344-6223. Article.

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DOI: 10.1016/j.legalmed.2014.09.001

Abstract

Blotters are usually impregnated with hallucinogens such as lysergic acid diethylamide (LSD); only rarely other psychoactive substances are detected. In this work we identified 4-bromo-2,5-dimethoxyamphetamine (DOB) and 2,5-dimethoxyamphetamine (DMA) in illicit blotters seized in Italy. This report describes a rapid method for the simultaneous identification and quantitation of DOB and its precursor (DMA) by liquid chromatography tandem mass spectrometry (LC–MS–MS), using 2,3-dimethoxyphenethylamine-d3 as internal standard. Regression equations were linear over the tested concentration range with good correlation coefficients. The achieved levels of sensitivity may be suitable to confirm the possible presence of DOB and DMA also in low concentration or in traces in seized material for forensic analysis. The developed method showed good reproducibility and sensitivity, and could be used for similar routine analysis. To our knowledge, this is the first report describing the detection of DOB and DMA from blotters.

Item Type:Article
ID Code:10583
Status:Published
Refereed:Yes
Uncontrolled Keywords:Amphetamine designer drugs, 4-Bromo-2,5-dimethoxyamphetamine (DOB), 2,5-Dimethoxyamphetamine (DMA), blotter, LC–MS–MS
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Elsevier
ISSN:1344-6223
Deposited On:12 Jan 2015 09:41

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