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Studio della trasmissione dopaminergica e del metabolismo energetico striatale in modelli animali di Parkinson

Bazzu, Gianfranco (2009) Studio della trasmissione dopaminergica e del metabolismo energetico striatale in modelli animali di Parkinson. Doctoral Thesis.

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Abstract

Parkinson’s desease (PD) is characterized by a selective loss of neurons in the substantia nigra pars compacta and a significant reduction of neostriatal content of dopamine (DA) and its major acidic metabolites DOPAC and homovanillic acid. MPTP is known to cause parkinsonism in human and this fact is a major incentive for using this toxin as an animal model of PD. In this study C57BL/6 mice were given MPTP in a sub-acute regimen, that induce tissue striatal DA depletion and nigral neuron death, and sub-chronic regimen, that induce in freely moving mice behavioural impairment and prolonged release of striatal DA. Such DA release may be considered the first step in MPTP-induced striatal DA depletion. Wistar rats were given MPTP for 3 consecutive days (respectively 25, 15, 10 mg/Kg/day) to study, by microdialysis, DA depletion, energetic metabolism and energy requirements during neuronal activation. Sistemically-administered MPTP induced a decrese in striatal glucose level and an increse in lactate and lactate/pyruvate (L/P) ratio levels in contrast with damphetamine that not affect L/P ratio. A new α-synuclein based model of PD in Wistar rats, more stable than MPTP model, has been proposed as a new frontier to evaluate the potential role of adult stem cells in an attempt of restorative therapy in PD.

Item Type:Doctoral Thesis
ID Code:1057
Publisher:Universita' degli studi di Sassari
Uncontrolled Keywords:Parkinson's desease, MPTP, α-synuclein, dopamine, energetic metabolism
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Cicli, scuole e corsi:Ciclo 21 > Corsi > Neuroscienze
Deposited On:18 Aug 2009 10:04

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