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Vanadium complexes as prospective therapeutics: structural characterization of a VIV lysozyme adduct

Santos, Marino F. A. and Correia, Isabel and Oliveira, Ana R. and Garribba, Eugenio and Pessoa, João Costa and Santos-Silva, Teresa (2014) Vanadium complexes as prospective therapeutics: structural characterization of a VIV lysozyme adduct. European Journal of Inorganic Chemistry, Vol. 2014 (21), p. 3293-3297. eISSN 1099-0682. Article.

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DOI: 10.1002/ejic.201402408

Abstract

The biological activity of vanadium complexes, namely, as insulin enhancers, is well known. We report a combined X-ray crystallography, electron paramagnetic resonance, and density functional theory study of the interaction of vanadium picolinate complexes with hen egg white lysozyme (HEWL). We show that the VIVO(pic)2 complex covalently binds to the COO group of the side chain of Asp52 of HEWL. The long VIV=O bond obtained in the X-ray study is explained to be due to reduction of VIV to VIII during exposure of the crystals to the intense X-ray beam.

Item Type:Article
ID Code:10518
Status:Published
Refereed:Yes
Uncontrolled Keywords:Vanadium, protein adducts, medicinal chemistry, EPR spectroscopy, density functional calculations
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 02 Centri > Centro di eccellenza interdisc. sviluppo ricerca biotecnologica e studio biodiversità della Sardegna e dell'area mediterranea
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Wiley
eISSN:1099-0682
Deposited On:03 Dec 2014 17:13

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