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Identification of HER2 protein overexpression and gene amplification in gastric cancer

Van Trung, Nghia (2015) Identification of HER2 protein overexpression and gene amplification in gastric cancer. Doctoral Thesis.

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Abstract

Gastric cancer is a leading cause of cancer related mortality, and current treatment outcomes for advanced disease remain poor. HER2 protein overexpression and gene amplification are significant biomarkers for identifying gastric cancer patients who possibly respond to HER2-targeted therapy using trastuzumab.
The aim of this study was to identify prevalence rate of HER2 gene amplification/overexpression in a local population, and determine the concordance rate between IHC and FISH techniques.
Formalin-fixed, paraffin-embedded sections of 43 adenocarcinoma specimens from 61 cases of gastric cancer patients were analyzed. Protein expression was assessed using immunohistochemistry and gene amplification was evaluated by fluorescence in situ hybridization.
11.7% (5/43) and 7,5% (3/40) of gastric adenocarcinomas displayed HER2 protein overexpression (score 3+/2+) and gene amplification, respectively. The concordance between IHC and FISH is high.

Item Type:Doctoral Thesis
ID Code:10440
Contributors:Tanda, Francesco
Publisher:Università degli studi di Sassari
Uncontrolled Keywords:HER2, gastric cancer, FISH, fluorescence in situ hybridization, IHC, immunohistochemistry
Subjects:Area 06 - Scienze mediche > MED/08 Anatomia patologica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Cicli, scuole e corsi:Ciclo 27 > Biomolecular and Biotechnological Sciences > Biochimica clinica e Proteomica clinica
Deposited On:18 Mar 2015 12:48

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