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Influenza della presenza di metalli e antiossidanti sullo sviluppo e decorso clinico della poliposi rinosinusale

Melis, Andrea (2015) Influenza della presenza di metalli e antiossidanti sullo sviluppo e decorso clinico della poliposi rinosinusale. Doctoral Thesis.

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Aim: Prevalence of nasal polyposis is about 4%, but its pathogenesis is still unknown. The aim of this work is to evaluate the presence of metals in nasal polyps tissues and to investigate the role of trace elements and
antioxidants on nasal polyposis developing and clinic. The metals and antioxidant enzyme levels measured in nasal polyps of 58 patients were compared with the levels measured in nasal biopsies of healthy patients.
Methods: 58 adult patients with nasal polyposis and 29 healthy patients were prospectively enrolled from June 2012 to August 2014. Clinical disease severity was measured by computed tomography and endoscopy (Stammberger score). Polyp samples and nasal mucosa were collected by outpatient biopsy during FESS and analysed through electron microscopy TEM and SEM to analyze ultra-structural morphology. In each sample we searched metals (cadmium, copper, aluminium, zinc, lead, manganese, selenium, cobalt and iron) through high resolution mass spectrometry (HR-ICP-MS).
Results: With electron microscopy we observed significant ultrastructural alterations in the samples of polyps compared to samples of healthy mucous. All metals have been detected in high concentrations in healthy samples compared to polyps samples (p< 0,001).
Conclusion: Results analyzed by the various methods used in the study may be a demonstration of an improvement of oxidative stress that can influence rhinosinusal polyposis developing and clinic.

Item Type:Doctoral Thesis
ID Code:10371
Contributors:Meloni, Francesco
Publisher:Università degli studi di Sassari
Uncontrolled Keywords:Metalli, poliposi rinosinusale, stress ossidativo, spettrometria di massa, microscopia elettronica
Subjects:Area 06 - Scienze mediche > MED/31 Otorinolaringoiatria
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Cicli, scuole e corsi:Ciclo 26 > Scienze biomediche > Epidemiologia molecolare dei tumori
Deposited On:18 Mar 2015 10:26

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