Pasquali, Sandro and Montesco, Maria Cristina and Ginanneschi, Chiara and Baroni, Gianna and Miracco, Clelia and Urso, Carmelo and Mele, Fabio and Lombardi, Anna Rita and Quaglino, Pietro and Cattaneo, Laura and Staibano, Stefania and Botti, Gerardo and Visca, Paolo and Zannoni, Marina and Soda, Giuseppe and Corti, Barbara and Pilloni, Luca and Anselmi, Luca and Lissia, Amelia and Vannucchi, Margherita and Manieli, Cristina and Massi, Daniela (2014) Lymphatic and blood vasculature in primary cutaneous melanomas of the scalp and neck. Head & neck , in press. ISSN 1043-3074. eISSN 1097-0347. Article.
Full text not available from this repository.
Background Scalp/neck melanomas have a poor prognosis, possibly because of a rich vascular supply that prompts tumor cells' dissemination.
Methods We compared the accuracy of immunohistochemical (IHC) staining with morphology for the identification of lymphovascular invasion in 156 scalp/neck melanomas. We then analyzed the association of vessel invasion and density with pathological features and survival.
Results IHC-detected lymphatic vessel invasion (LVI) and blood vessel invasion (BVI) were identified in 34.6% and 13.5% of cases, respectively. IHC increased the LVI/BVI detection compared to morphology (40.4% vs 16.6%; p <.001). The degree of peritumoral and intratumoral blood vessel density (BVD) was greater than lymphatic vessel density (LVD). Ulceration was the only factor independently associated with intratumoral (p = .029) and peritumoral (p = .047) BVD. Tumor thickness was the only independent predictor of survival (p = .002).
Conclusion IHC allows accurate assessment of lymphovascular invasion in scalp/neck melanomas. In these tumors, we observed a high incidence of BVI, which deserves further investigations.
I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore
Repository Staff Only: item control page