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Effect of chitosan concentration on PLGA microcapsules for controlled release and stability of resveratrol

Sanna, Vanna Annunziata and Roggio, Anna Maria and Pala, Nicolino and Marceddu, Salvatore and Lubinu, Giuseppe and Mariani, Alberto and Sechi, Mario (2015) Effect of chitosan concentration on PLGA microcapsules for controlled release and stability of resveratrol. International Journal of Biological Macromolecules, Vol. 72 , p. 531-536. ISSN 0141-8130. Article.

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DOI: 10.1016/j.ijbiomac.2014.08.053

Abstract

The polyphenols as nutraceutical and therapeutic agents are gaining growing interest for their beneficial effects and potential in human health. In order to protect their scaffolds and functionality, and to improve the bioavailability, the microencapsulation can represent a promising strategy.
This study reports on the formulation of the natural resveratrol (RSV) into microcapsules (MCs) prepared by using different concentrations of chitosan (CS) and poly(D,L-lactic-co-glycolic acid) (PLGA) as polymeric matrix. MCs were prepared by W/O/W double emulsion method and characterized in terms of morphology, size, encapsulation efficiency, physicochemical and thermal properties. RSV release behavior from MCs was evaluated under simulated gastrointestinal fluids, and the long term stability was monitored at different storage conditions.
MCs resulted to have spherical shape and different morphology, with size ranging from 11 to 20 μm, and encapsulation efficiencies of 40–52%, depending on the CS concentration. Moreover, MCs containing CS exhibited a significant lower release of RSV than those containing only PLGA. Furthermore, all tested formulations were able to ensure a good retention and stability of encapsulated RSV until 6 months.
In summary, CS/PLGA MCs can be proposed as an attractive delivery system to control the release and long term protection of RSV.

Item Type:Article
ID Code:10328
Status:Published
Refereed:Yes
Uncontrolled Keywords:Resveratrol, chitosan, poly (D,L-lactic-co-glycolic acid), microcapsules
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Area 03 - Scienze chimiche > CHIM/04 Chimica industriale
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > Porto Conte Ricerche, Alghero
002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di scienze delle produzioni alimentari, Sassari
001 Università di Sassari > 02 Centri > Nanoworld Institute, Nanoscience Laboratories, Sassari Unit
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Elsevier
ISSN:0141-8130
Deposited On:19 Nov 2014 14:57

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