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In vitro inhibitory effects of Sardinian Pistacia lentiscus L. and Pistacia terebinthus L. on metabolic enzymes: pancreatic lipase, α-amylase, and α-glucosidase

Foddai, Marzia and Kasabri, Violet and Afifi, Fatma U. and Azara, Emanuela and Petretto, Giacomo Luigi and Pintore, Giorgio Antonio Mario (2015) In vitroinhibitory effects of Sardinian Pistacia lentiscus L. and Pistacia terebinthus L. on metabolic enzymes: pancreatic lipase, α-amylase, and α-glucosidase. Starch, Vol. 67 (1-2), p. 204-212. eISSN 1521-379X. Article.

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DOI: 10.1002/star.201400068

Abstract

Pancreatic triacylglycerol lipase (PL), α-amylase, and α-glucosidase are appealing pharmacological targets for the management of dyslipidemia, atherosclerosis, and obesity-diabetes. Presently, in vitro screening for considerable inhibition of these digestive hydrolases by endemic Sardinian Pistacia lentiscus L. and P. terebinthus L. leaves and fruits aqueous extracts (AEs) (Anacardiaceae) was undertaken. The AEs PL-IC50 (µg/mL) in an ascending order were: P. lentiscus leaves; 6.1 ± 0.2<P. terebinthus leaves; 9.0 ± 0.4< P. terebinthus fruits; 125.2 ± 12.1<P. lentiscus fruits; 230.7 ± 38.4. Comparable to acarbose, all different parts of Sardinian Pistacia spp. AEs were identified as in vitro potent and efficacious dual inhibitors of α-amylase and α-glucosidase with respective IC50: P. lentiscus leaves; 65.3 ± 7.4 µg/mL<P. terebinthus leaves; 76.5 ± 4.5 µg/mL<P. terebinthus fruits; 237.7 ± 33.5 µg/mL<P. lentiscus fruits; 1.4 ± 0.2 mg/mL. Taken together, Sardinian Pistacia spp. as functional foods and nutraceuticals modulating gastrointestinal carbohydrate and lipid digestion and absorption, maybe be advocated as potential candidate for obesity-diabetes prevention and phytotherapy.

Item Type:Article
ID Code:10317
Status:Published
Refereed:Yes
Uncontrolled Keywords:α-amylase and α-glucosidase, orlistat and acarbose, pancreatic lipase, Pistacia lentiscus L., Pistacia terebinthus L. (Anacardiaceae)
Subjects:Area 05 - Scienze biologiche > BIO/15 Biologia farmaceutica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Wiley
eISSN:1521-379X
Deposited On:14 Nov 2014 14:51

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