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Liver melanomacrophage centres as indicators of Atlantic bluefin tuna, Thunnus thynnus L. well-being

Passantino, Letizia and Santamaria, Nicoletta and Zupa, Rosa and Pousis, Chrysovalentinos and Garofalo, Rita and Cianciotta, Attilio and Jirillo, Emilio and Acone, Franca and Corriero, Aldo (2014) Liver melanomacrophage centres as indicators of Atlantic bluefin tuna, Thunnus thynnus L. well-being. Journal of Fish Deseases, Vol. 37 (3), p. 241-250. eISSN 1365-2761. Article.

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DOI: 10.1111/jfd.12102

Abstract

Melanomacrophage centres (MMCs), located in different organs of non-mammalian vertebrates, play a role in the destruction, detoxification or recycling of endogenous and exogenous materials. Cytochrome P450 monoxygenase 1A (CYP1A) is involved in xenobiotics biotransformation, and its liver expression is considered as a biomarker for detecting exposure to environmental pollutants. Atlantic bluefin tuna (ABFT), Thunnus thynnus L., liver samples were collected from: wild animals caught in the eastern Atlantic; juveniles reared in the central Adriatic; juveniles reared in the northern Adriatic; adults reared in the western Mediterranean. The samples were processed for basic histology, histochemistry and for CYP1A immunodetection. An unexpected high density of MMCs, containing ferric iron and lipofuscin–ceroids, was detected in the juveniles sampled in the northern Adriatic Sea. These individuals showed also a strong anti-CYP1A immunopositivity in hepatocytes and in the epithelium of bile ducts. This study supports the utility of MMCs as biomarkers of fish ‘health status’ and gives concern for a potential contaminant accumulation in ABFT.

Item Type:Article
ID Code:10311
Status:Published
Refereed:Yes
Uncontrolled Keywords:Bluefin tuna, cytochrome P450 monoxygenase 1A, liver, melanomacrophage centres
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/01 Anatomia degli animali domestici
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Veterinaria
Publisher:John Wiley & Sons
eISSN:1365-2761
Deposited On:14 Nov 2014 13:50

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