Gloria-Bottini, Fulvia and Saccucci, Patrizia and Meloni, Gianfranco and Bottini, Egidio (2014) Further observations on associations between the ADA gene and past malaria morbidity in Sardinia. American journal of human biology, Vol. 26 (5), p. 716-718. ISSN 1042-0533. eISSN 1520-6300. Article.
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Objectives: Adenosine Deaminase (ADA) contributes to the regulation of adenosine concentration and in turn to T
cell activation. Genetic variability of ADA activity may have, therefore, an important role in resistance to malaria.
Indeed, previous studies in Sardinia have shown a lower frequency of ADA1*2 allele (associated with low ADA activity) in areas, where malaria was heavily endemic compared to areas where malaria was not endemic. We have now studied the ADA2 locus, another polymorphic site with two alleles ADA2 *1 and ADA2 *2 within the ADA gene.
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