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Electron-transfer-induced reductive dealkoxylation of alkyl aryl ethers. III. Reductive cleavage of methoxy-substituted N,N-dimethylanilines (N,N-dimethylanisidines)

Azzena, Ugo Gavino and Dessanti, Francesca and Melloni, Giovanni and Pisano, Luisa (2002) Electron-transfer-induced reductive dealkoxylation of alkyl aryl ethers. III. Reductive cleavage of methoxy-substituted N,N-dimethylanilines (N,N-dimethylanisidines). ARKIVOC, Vol. 2002 (v), p. 181-188. ISSN 1424-6376. Article.

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Abstract

The reactivity of the three isomeric methoxy-substituted N,N-dimethylanilines (N,N-dimethylanisidines) and of N,N-dimethyl-2,6-dimethoxyaniline in the reduction with alkali metals in aprotic solvents was investigated. N,N-Dimethyl-p-methoxyaniline was found to be unreactive, while the other substrates underwent exclusive cleavage of carbon-oxygen bond(s), with the following order of reactivity: 2,6-dimethoxy > o-methoxy > m-methoxy > p-methoxy. Both the relative reactivity and the regioselectivity of cleavage (demethoxylation vs. demethylation) was found to parallel closely that of the corresponding di- and trimethoxysubstituted substrates. These results suggest that intermediates with different electron distribution or even different intermediates are involved in the reductive cleavage of aryl-oxygen and arylnitrogen bonds.

Item Type:Article
ID Code:1026
Status:Published
Refereed:Yes
Uncontrolled Keywords:Electron-transfer, reduction, bond cleavage, alkali metals, aromatic ethers
Subjects:Area 03 - Scienze chimiche > CHIM/06 Chimica organica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
Publisher:ARKAT USA
ISSN:1424-6376
Publisher Policy:Depositato per gentile concessione dell'Editore
Additional Information:Pubblicato online il 25 aprile 2002.
Deposited On:18 Aug 2009 10:04

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