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Synthesis of pyrrolo[1,2-a]indole-1,8(5H)-diones as new synthons for developing novel tricyclic compounds of pharmaceutical interest

Sechi, Mario and Mura, Alessio and Sannia, Luciano and Orecchioni, Maria and Paglietti, Giuseppe (2004) Synthesis of pyrrolo[1,2-a]indole-1,8(5H)-diones as new synthons for developing novel tricyclic compounds of pharmaceutical interest. ARKIVOC, Vol. 2004 (Part 5), p. 97-106. ISSN 1424-6376. Article.

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Abstract

In the course of our work aimed at developing novel heterocycles of pharmaceutical interest, a new tricycle, the tetrahydropyrrolo[1,2-a]indole-1,8-dione, has been synthesized by an intramolecular Friedel-Crafts acylation, as a synthon suitable to be functionalized to give novel compounds with potential biological properties. Also, an unusual nucleophilic α-addition to methyl propiolate by 1,5,6,7-tetrahydro-4H-indol-4-one was observed and discussed.

Item Type:Article
ID Code:1025
Status:Published
Refereed:Yes
Uncontrolled Keywords:Tetrahydropyrrolo-[1,2-a]indole-1,8-dione, intramolecular Friedel-Crafts, Michaeltype α-addition
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:ARKAT USA
ISSN:1424-6376
Publisher Policy:Depositato per gentile concessione dell'Editore
Additional Information:Pubblicato online il 14 febbraio 2004.
Deposited On:18 Aug 2009 10:04

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