Camiolo, Salvatore and Melito, Sara and Milia, Giampiera and Porceddu, Andrea (2014) Seforta, an integrated tool for detecting the signature of selection in coding sequences. BMC Research Notes, Vol. 7 (240), p. 3. ISSN 1756-0500. Article.
Background: The majority of amino acid residues are encoded by more than one codon, and a bias in the usage of such synonymous codons has been repeatedly demonstrated. One assumption is that this phenomenon has evolved to improve the efficiency of translation by reducing the time required for the recruitment of isoacceptors. The most abundant tRNA species are preferred at sites on the protein which are key for its functionality, a behavior which has been termed “translational accuracy”. Although observed in many species, as yet no public domain software has been made available for its quantification.
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