Pani, Giovanna and Scherm, Barbara and Azara, Emanuela and Balmas, Virgilio and Jahanshiri, Zahra and Carta, Paola and Fabbri, Davide and Dettori, Maria Antonietta and Fadda, Angela and Dessì, Alessandro and Dallocchio, Roberto and Migheli, Quirico and Delogu, Giovanna (2014) Natural and natural-like phenolic inhibitors of type B trichothecene in vitro production by the wheat (Triticum sp.) pathogen Fusarium culmorum. Journal of Agricultural and Food Chemistry, Vol. 62 (22), p. 4969-4978. ISSN 0021-8561. eISSN 1520-511. Article.
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Fusarium culmorum, a fungal pathogen of small grain cereals, produces 4-deoxynivalenol and its acetylated derivatives that may cause toxicoses on humans or animals consuming contaminated food or feed. Natural and natural-like compounds belonging to phenol and hydroxylated biphenyl structural classes were tested in vitro to determine their activity on vegetative growth and trichothecene biosynthesis by F. culmorum. Most of the compounds tested at 1.5 or 1.0 mM reduced 3-acetyl-4-deoxynivalenol production by over 70% compared to the control, without affecting fungal growth significantly. Furthermore, several compounds retained their ability to inhibit toxin in vitro production at the lowest concentrations of 0.5 and 0.25 mM. Magnolol 27 showed fungicidal activity even at 0.1 mM. No linear correlation was observed between antioxidant properties of the compounds and their ability to inhibit fungal growth and mycotoxigenic capacity. A guaiacyl unit in the structure may play a key role in trichothecene inhibition.
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