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The “CROMa” project: a care pathway for clinical management of patients with bisphosphonate exposure

Capocci, Mauro and Romeo, Umberto and Cocco, Fabio and Bignozzi, Isabella and Annibali, Susanna and Ottolenghi, Livia (2014) The “CROMa” project: a care pathway for clinical management of patients with bisphosphonate exposure. International journal of dentistry, Vol. 2014 (Article ID 719478). ISSN 1687-8728. eISSN 1687-8736. Article.

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DOI: 10.1155/2014/719478

Abstract

Aim. To describe 7 years of activity of “CROMa” (Coordination of Research on Osteonecrosis of the Jaws) project of “Sapienza” University of Rome. Materials and Methods. A preventive and therapeutic care pathway was created for patients with bisphosphonates (BPs) exposure. Demographic, social, behavioural, pharmacological, and clinical variables were registered in a dedicated database. Results. In the project, 502 patients, 403 females and 99 males, were observed. Bone pathologies were 79% osteometabolic diseases (OMD) and 21% metastatic cancer (CA). Females were 90% in OMD group and 41% in CA. BP administration was 54% oral, 31% IV, and 11% IM; 89% of BPs were amino-BP and 11% non-amino-BP. Consistently with bone pathology (OMD/CA), alendronate appears to be prevalent for OMD (40% relative), while zoledronate was indicated in 92% of CA patients. Out of 502 cases collected, 28 BRONJ were detected: 17 of them were related to IV BP treatment. Preventive oral assessment was required for 50% of CA patients and by 4% of OMD patients. Conclusions. The proposed care pathway protocols for BP exposed patients appeared to be useful to meet treatment and preventive needs, in both oncological and osteometabolic diseases patients. Patients’ and physicians’ prevention awareness can be the starting point of a multilevel prevention system.

Item Type:Article
ID Code:10163
Status:Published
Refereed:Yes
Uncontrolled Keywords:CROMa project, patients, bisphosphonate exposure
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Chirurgiche, Microchirurgiche e Mediche
Publisher:Hindawi Publishing Corporation
ISSN:1687-8728
eISSN:1687-8736
Copyright Holders:© 2014 Mauro Capocci et al.
Deposited On:08 Oct 2014 17:27

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