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Iron chelating agents for iron overload diseases

Crisponi, Guido and Nurchi, Valeria Marina and Zoroddu, Maria Antonietta (2014) Iron chelating agents for iron overload diseases. Thalassemia reports, Vol. 4 (2), p. 2046. eISSN 2039-4365. Article.

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DOI: 10.4081/thal.2014.2046

Abstract

Although iron is an essential element for life, an excessive amount may become extremely toxic both for its ability to generate reactive oxygen species, and for the lack in humans of regulatory mechanisms for iron excretion. Chelation therapy has been introduced in clinical practice in the seventies of last century to defend thalassemic patients from the effects of iron overload and, in spite of all its limitations, it has dramatically changed both life expectancy and quality of life of patients. It has to be considered that the drugs in clinical use present some disadvantages too, this makes urgent new more suitable chelating agents. The requirements of an iron chelator have been better and better defined over the years and in this paper they will be discussed in detail. As a final point the most interesting ligands studied in the last years will be presented.

Item Type:Article
ID Code:10160
Status:Published
Refereed:Yes
Uncontrolled Keywords:Iron chelator, b-thalassemia, pFe, hydroxypyridinone, deferoxamine
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Pagepress
eISSN:2039-4365
Deposited On:08 Oct 2014 14:36

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