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Early BCG vaccination is unrelated to pulmonary immunity against Mycobacterium tuberculosis in adults

Herzmann, Christian and Sotgiu, Giovanni and Schaberg, Tom and Ernst, Martin and Stenger, Steffen and Lange, Christoph (2014) Early BCG vaccination is unrelated to pulmonary immunity against Mycobacterium tuberculosis in adults. European Respiratory Journal, Vol. 44 (4), p. 1087-1090. ISSN 0903-1936. eISSN 1399-3003. Article.

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DOI: 10.1183/09031936.00086514

Abstract

Vaccination with Mycobacterium bovis bacille Calmette–Guérin (BCG) is performed for the prevention of tuberculosis. M. bovis BCG vaccination is among the most commonly applied of all vaccines worldwide. M. bovis BCG vaccination efficiently reduces the morbidity and mortality of tuberculosis in children, especially miliary tuberculosis and meningitis.
Although recent investigations of Mycobacterium tuberculosis-specific immune responses by interferon-γ release assays (IGRAs) provide evidence on the effect of M. bovis BCG vaccination on the prevention of primary infection with M. tuberculosis 3–5, it has been suggested that this effect diminishes during adolescence 2, 6. Consequently, adults are probably not protected from pulmonary tuberculosis by BCG vaccination.
To date, no study has investigated the impact of M. bovis BCG vaccination performed in childhood on pulmonary immune responses in adults. The objective of this study was to assess the effect of childhood M. bovis BCG vaccination on systemic and pulmonary immune responses to M. tuberculosis in healthy adult individuals exposed to patients with acid-fast bacilli (AFB)-positive sputum smear-positive tuberculosis in Germany.
An observational, cross-sectional, multicentre study was conducted by the German Ministry of Education and Research-funded research consortium on “Pulmonary Tuberculosis – Host and Pathogen Determinants of Resistance and Disease Progression (TB or Not TB)”. Healthcare workers (HCWs) with 1) ongoing.

Item Type:Article
ID Code:10110
Status:Published
Refereed:Yes
Uncontrolled Keywords:Mycobacterium bovis, M. bovis Bacille Calmette–Guérin (BCG) vaccination, interferon-γ release assays (IGRAs)
Subjects:Area 06 - Scienze mediche > MED/01 Statistica medica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > AOU -Azienda Ospedaliero Universitaria, Sassari
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:European Respiratory Society Journals
ISSN:0903-1936
eISSN:1399-3003
Deposited On:18 Sep 2014 11:23

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