titoli, abstracts, parole chiave >>>
Recognition of zinc transporter 8 and MAP3865c homologous epitopes by Hashimoto's Thyroiditis subjects from Sardinia: a common target with type 1 diabetes?

Masala, Speranza and Cossu, Davide and Palermo, Mario and Sechi, Leonardo Antonio (2014) Recognition of zinc transporter 8 and MAP3865c homologous epitopes by Hashimoto's Thyroiditis subjects from Sardinia: a common target with type 1 diabetes? PLoS One, Vol. 9 (5), e97621. ISSN 1932-6203. Article.

[img]
Preview
Full text disponibile come PDF Richiede visualizzatore di PDF come GSview, Xpdf o Adobe Acrobat Reader
Available under License Creative Commons Attribution.

843Kb

DOI: 10.1371/journal.pone.0097621

Abstract

Mycobacterium avium subspecies paratuberculosis (MAP) asymptomatic infection has been previously linked to Type 1 diabetes (T1D) and Multiple Sclerosis. An association between MAP infection and Hashimoto's thyroiditis (HT) was also proposed only in a case report. This study aimed to investigate the robustness of the latter association, testing a large cohort of HT and healthy control (HCs) subjects, all from Sardinia. Prevalence of anti-MAP3865c Abs was assessed by indirect enzyme-linked immunosorbent assay (ELISA). Moreover, given that human ZnT8 is specifically expressed in the pancreatic β-cells, in the follicle epithelial cells and in the parafollicular cells of the thyroid gland, we also tested ZnT8 epitopes homologues to the MAP3865c immunodominant peptides previously identified. Indeed, Abs targeting MAP3865c and ZnT8 homologous regions display similar frequencies in patients and controls, thus suggesting that Abs recognizing these epitopes could be cross-reactive. A statistically significant difference was found between HT patients and HCs when analyzing the humoral response mounted against MAP3865c/ZnT8 homologues epitopes. To our knowledge, this is the first report, which provides statistically significant evidence sustaining the existence of an association between MAP sero-reactivity and HT. Further studies are required to investigate the relevance of MAP to HT, aimed at deciphering if this pathogen can be at play in triggering this autoimmune disease. Likewise, genetic polymorphism of the host, and other environmental factors need to be investigated.

Item Type:Article
ID Code:10101
Status:Published
Refereed:Yes
Uncontrolled Keywords:Hashimoto’s Thyroiditis, Mycobacterium avium, paratuberculosis, Sardinia
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > Azienda ASL1, Sassari
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Public Library of Science
ISSN:1932-6203
Copyright Holders:© 2014 Masala et al.
Deposited On:17 Sep 2014 12:35

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page