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Prevalence of intratubular germ cell neoplasia and multifocality in testicular germ cell tumors ≤ 2 cm: relationship with other pathological features

Favilla, Vincenzo and Russo, Giorgio Ivan and Spitaleri, Fabio and Urzì, Daniele and Madonia, Massimo and La Vignera, Sandro and Condorelli, Rosita and Calogero, Aldo Eugenio and Cimino, Sebastiano and Morgia, Giuseppe (2015) Prevalence of intratubular germ cell neoplasia and multifocality in testicular germ cell tumors ≤ 2 cm: relationship with other pathological features. Clinical Genitourinary Cancer, Vol. 13 (1), e31-e35. ISSN 1558-7673. Article.

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DOI: 10.1016/j.clgc.2014.06.009

Abstract

Introduction: The aim of this study was to determine the prevalence of TIN and multifocality in men undergoing radical orchiectomy for testicular germ cell tumor (TGCT), and among those with a main tumor size ≤ 2 cm, potentially eligible for testis-sparing surgery.

Patients and Methods: Orchiectomy specimens from 126 consecutive patients treated for TGCT tumor between 2003 and 2012 were included. Multifocality was defined as a distinct tumor focus with a diameter ≥ 1 mm separable from the main tumor mass. Uni- and multivariate logistic regression was performed to identify the association between pathological variables and multifocality and to identify variables for predicting clinical stage II to III and pathological stage ≥ pT2.

Results: Of the 126 patients, 103 (82.0%) had clinical stage I cancer at presentation and 23 (18.0%) had clinical stage II to III. The median size of the primary tumor mass was 3.7 cm (range, 0.5-12 cm) in multifocality and 3.0 cm (range, 0.6-8.0 cm) in monofocality, respectively (P < .05). The prevalence of multifocality and TIN was lower in the presence of a smaller main tumor mass (≤ 1 cm) compared with tumors 1.1 to 2.0 cm (P < .05), and increased when the index mass tumor diameter was ≥ 2 cm (P trend < .05). No association was found between tumor histology and multifocality (P = .95) or TIN (P = .54) using the χ2 test.

Conclusion: The prevalence of multifocality and TIN was decreased in smaller tumors (≤ 1 cm) and increased when the index mass tumor diameter was ≥ 1.1 cm.

Item Type:Article
ID Code:10092
Status:Published
Refereed:Yes
Uncontrolled Keywords:Multifocality, testicular cancer, testis-sparing, TIN, tumor size
Subjects:Area 06 - Scienze mediche > MED/24 Urologia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Chirurgiche, Microchirurgiche e Mediche
Publisher:Elsevier
ISSN:1558-7673
Deposited On:15 Sep 2014 08:43

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