Crisponi, Guido and Nurchi, Valeria Marina and Lachowicz, Joanna I. and Crespo-Alonso, Miriam and Zoroddu, Maria Antonietta and Peana, Massimiliano Francesco (2014) Warns against unapproved ‘chelation therapy’. Journal of Biological Inorganic Chemistry, Vol. 19 (2 supplement), S711-S712 (AW 9). ISSN 0949-8257. eISSN 1432-1327. Article.
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At Eurobic11 in Granada we presented a Keynote Lecture on chelation therapy, a consolidated medical procedure used primarily to hinder the effects of toxic metal ions on human tissues. Its application spans a broad spectrum of serious disorders, ranging from acute metal intoxication to genetic metal-overload. The use of chelating agents is compromised by a number of serious side effects, mainly attributable to perturbed equilibrium of essential metal ion homeostasis and dislocation of complexed metal ions to dangerous body sites. For this reason, chelation therapy has been limited to specific critical and otherwise untreatable conditions and it needs to be monitored within an appropriate clinical context.
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