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Oxidative stress-dependent activation of collagen synthesis is induced in human pulmonary smooth muscle cells by sera from patients with scleroderma-associated pulmonary hypertension

Boin, Francesco and Erre, Gian Luca and Posadino, Anna Maria and Cossu, Annalisa and Giordo, Roberta and Spinetti, Gaia and Passiu, Giuseppe and Emanueli, Costanza and Pintus, Gianfranco (2014) Oxidative stress-dependent activation of collagen synthesis is induced in human pulmonary smooth muscle cells by sera from patients with scleroderma-associated pulmonary hypertension. Orphanet Journal of Rare Deseases, Vol. 9 (123), p. 5. ISSN 1750-1172. Article.

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DOI: 10.1186/s13023-014-0123-7

Abstract

Pulmonary arterial hypertension is a major complication of systemic sclerosis. Although oxidative stress, intima hyperplasia and a progressive vessel occlusion appear to be clearly involved, the fine molecular mechanisms underpinning the onset and progression of systemic sclerosis-associated pulmonary arterial hypertension remain largely unknown. Here we shows for the first time that an increase of NADPH-derived reactive oxygen species production induced by sera from systemic sclerosis patients with pulmonary arterial hypertension drives collagen type I promoter activity in primary human pulmonary artery smooth muscle cells, suggesting that antioxidant-based therapies should be considered in the treatment of systemic sclerosis-associated vascular diseases.

Item Type:Article
ID Code:10051
Status:Published
Refereed:Yes
Uncontrolled Keywords:Systemic sclerosis, pulmonary arterial hypertension, oxidative stress, vascular smooth muscle cells
Subjects:Area 06 - Scienze mediche > MED/16 Reumatologia
Area 05 - Scienze biologiche > BIO/10 Biochimica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:BioMed Central
ISSN:1750-1172
Copyright Holders:© 2014 Boin et al. ; Licensee Biomedcentral Ltd
Deposited On:11 Sep 2014 09:23

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