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Immunomodulatory properties of carbon nanotubes are able to compensate immune function dysregulation caused by microgravity conditions

Crescio, Claudia and Orecchioni, Marco and Menard-Moyon, Cécilia and Sgarrella, Francesco and Pippia, Proto Gavino and Manetti, Roberto and Bianco, Alberto and Delogu, Lucia Gemma (2014) Immunomodulatory properties of carbon nanotubes are able to compensate immune function dysregulation caused by microgravity conditions. Nanoscale, Vol. 6 (16), p. 9599-9603. ISSN 2040-3364. eISSN 2040-3372. Article.

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DOI: 10.1039/C4NR02711F

Abstract

Spaceflights lead to dysregulation of the immune cell functionality affecting the expression of activation markers and cytokine production. Short oxidized multi-walled carbon nanotubes functionalized by 1,3-dipolar cycloaddition have been reported to activate immune cells. In this Communication we have performed surface marker assays and multiplex ELISA on primary monocytes and T cells under microgravity. We have discovered that carbon nanotubes, through their immunostimulatory properties, are able to fight spaceflight immune system dysregulations.

Item Type:Article
ID Code:10023
Status:Published
Refereed:Yes
Uncontrolled Keywords:Immune cell functionality, 1,3-dipolar cycloaddition, ELISA, microgravity
Subjects:Area 05 - Scienze biologiche > BIO/10 Biochimica
Area 05 - Scienze biologiche > BIO/09 Fisiologia
Area 06 - Scienze mediche > MED/09 Medicina interna
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:Royal Society of Chemistry
ISSN:2040-3364
eISSN:2040-3372
Deposited On:11 Sep 2014 08:53

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