Crescio, Claudia and Orecchioni, Marco and Menard-Moyon, Cécilia and Sgarrella, Francesco and Pippia, Proto Gavino and Manetti, Roberto and Bianco, Alberto and Delogu, Lucia Gemma (2014) Immunomodulatory properties of carbon nanotubes are able to compensate immune function dysregulation caused by microgravity conditions. Nanoscale, Vol. 6 (16), p. 9599-9603. ISSN 2040-3364. eISSN 2040-3372. Article.
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Spaceflights lead to dysregulation of the immune cell functionality affecting the expression of activation markers and cytokine production. Short oxidized multi-walled carbon nanotubes functionalized by 1,3-dipolar cycloaddition have been reported to activate immune cells. In this Communication we have performed surface marker assays and multiplex ELISA on primary monocytes and T cells under microgravity. We have discovered that carbon nanotubes, through their immunostimulatory properties, are able to fight spaceflight immune system dysregulations.
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