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Serum free thyroxine levels are positively associated with arterial stiffness in the SardiNIA study

Delitala, Alessandro Palmerio and Orrù , Marco and Filigheddu, Fabiana and Pilia, Maria Grazia and Delitala, Giuseppe and Ganau, Antonello and Saba, Pier Sergio and Decandia, Federica and Scuteri, Angelo and Marongiu, Michele and Lakatta, Edward G. and Strait, James and Cucca, Francesco (2015) Serum free thyroxine levels are positively associated with arterial stiffness in the SardiNIA study. Clinical Endocrinology, Vol. 82 (4), p. 592-597. ISSN 0300-0664. eISSN 1365-2265. Article.

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DOI: 10.1111/cen.12532

Abstract

Objective:Thyroid dysfunction may accelerate atherosclerosis. Aortic pulse wave velocity (PWV) is an early index of arterial stiffness and an important risk factor for cardiovascular disease and might therefore be linked to changes in thyroid activity. We investigated the relationship between thyroid function and caro- tid-femoral PWV, as an index of arterial stiffness.
Design:Cross-sectional cohort study.
Patients:Participants from the SardiNIA study. Those being treated for thyroid diseases were excluded, yielding a sample of 5875 aged 14–102.
Measurements: Clinical parameters, blood tests including serum TSH and serum FT4, and carotid-femoral PWV were measured.
Results:After adjusting for confounders, a direct and linear association between FT4 and PWV was shown (multiple regres- sion analysis). The model containing age, mean blood pressure, body mass index, heart rate, FT4, hypertension, diabetes and dyslipidaemia accounted for 55% of the variation in PWV.
Conclusions: Like several other known risk factors, serum FT4 levels are associated with carotid-femoral PWV, suggesting that high FT4 levels have a detrimental effect on aortic stiff-ness and may contribute to ageing process of the vascular system. This finding may help to understand the pathogenesis of cardiovascular disease and contribute to improve prevention therapy.

Item Type:Article
ID Code:10015
Status:Published
Refereed:Yes
Uncontrolled Keywords:Thyroid dysfunction, atherosclerosis, carotid-femoral PWV, arterial stiffness, Sardinia
Subjects:Area 06 - Scienze mediche > MED/11 Malattie dell'apparato cardiovascolare
Area 06 - Scienze mediche > MED/09 Medicina interna
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > AOU -Azienda Ospedaliero Universitaria, Sassari
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:Blackwell / Wiley
ISSN:0300-0664
eISSN:1365-2265
Copyright Holders:© John Wiley & Sons
Deposited On:08 Aug 2014 11:38

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