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Is there a role for imatinib mesylate in the treatment of eosinophilic granulomatosis with polyangiitis?

Erre, Gian Luca and Pardini, Simonetta and Cuccuru, Luciana and Taras, Loredana and Passiu, Giuseppe (2015) Is there a role for imatinib mesylate in the treatment of eosinophilic granulomatosis with polyangiitis? Joint Bone Spine, Vol. 82 (1), p. 72-73. ISSN 1297-319X. Article.

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DOI: 10.1016/j.jbspin.2014.06.004

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic eosinophilic vasculitis, belonging to the group of ANCA-associated vasculitides (AAV). EGPA pathogenesis is still elusive, but a potential role for IL-5 and Eotaxins mediated eosinophil activation has been reported. Imatinib mesylate, a tyrosine kinase (TK) inhibitor, is approved for the treatment of chronic myeloid leukaemia and FIP1L1/PDGFRA positive gene fusion hypereosinophilia. A potential role for imatinib in the treatment of idiopathic hypereosinophilic syndrome (HES) and AAV has been recently proposed.

Item Type:Article
ID Code:10012
Status:Published
Refereed:Yes
Uncontrolled Keywords:Churg-Strauss syndrome, imatinib mesylate, anti-neutrophil cytoplasmic antibodies, eosinophilic granulomatosis with polyangiitis
Subjects:Area 06 - Scienze mediche > MED/16 Reumatologia
Area 06 - Scienze mediche > MED/15 Malattie del sangue
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > AOU -Azienda Ospedaliero Universitaria, Sassari
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:Elsevier Masson
ISSN:1297-319X
Deposited On:06 Aug 2014 16:33

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