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Novel type of VanB2 teicoplanin-resistant hospital-associated Enterococcus faecium

Santona, Antonella and Paglietti, Bianca and Al-Qahtani, Ahmed and Bohol, Marie Fe F. and Senok, Abiola and Deligios, Massimo and Rubino, Salvatore and Al-Ahdal, Mohammed N. (2014) Novel type of VanB2 teicoplanin-resistant hospital-associated Enterococcus faecium. International Journal of Antimicrobial Agents, Vol. 44 (2), p. 156-159. ISSN 0924-8579. Article.

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DOI: 10.1016/j.ijantimicag.2014.05.005

Abstract

Seven high-risk clones of vancomycin-resistant Enterococcus faecium (VREF) belonging to clonal complex 17 were identified using multilocus sequence typing (MLST) among clinical isolates from Saudi Arabia. Among these isolates, a new hospital-associated sequence type (ST795), VanB2-type teicoplanin-resistant strain was detected. Its unusual phenotype resulted from a new combination of mutations in the ddl, vans and vanW genes, which confirmed the trend of evolution in VanB-type resistance. Furthermore, characteristics of adaptation and persistence in the hospital environment of ST795 were emphasised by the presence of genes and clusters recognised to be specific for hospital-associated VREF.

Item Type:Article
ID Code:10010
Status:Published
Refereed:Yes
Uncontrolled Keywords:MLST, Hospital-associated, Enterococcus faecium, teicoplanin resistance mechanism
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Elsevier
ISSN:0924-8579
Deposited On:06 Aug 2014 14:09

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